Referral Conviction Playbook

Referral Conviction Playbook

The definitive guide to site best practices, visualizing how speed-to-lead drives candidate conviction and enrollment success.

“Data doesn’t enroll patients. People do.” — Bryan Manning, CEO of Clinical Enrollment
Pre-Screening Process
Online Screening Approx. 4 questions Screens out 30%
Phone Screening Approx. 18 questions Screens out 70%
Mother Goose Protocol Builds patient conviction
EMR Retrieval Data verified pre-intro
Patient Referred To You Begin the Journey

Path 1: Warm Transfer

Initial Connection
100%
Maximum Conviction: Patients are still in momentum. They are in flow. Immediate transfer yields flawless connection rates and makes the patient feel deeply cared for.
“I was so nervous, but talking to someone immediately calmed my nerves. I didn’t have time to second-guess.” — John F. (Patient)
“We were amazed how effective it was to simply have the patient transferred to us. We used to chase patients for weeks. Talking to them right away saves us hours of admin time.” — Dr. Marcus T. (CNS Site)
Screening Outcomes
72% On-Site Scheduled
18% EMR DNQ
10% No Longer Int.
On-Site Conversion
89%

On-Site to ICF Ratio

Final Enrollment
18% Under Average

Study average screen fail rate reduction.

Path 2: Scheduled Call

Initial Connection
72%
Structured Follow-Up: Clinical Enrollment provides 72, 24, and 1-hour follow-up reminders. Because the patient knows what to expect, 72% of these calls connect.
“I hate waiting around. Having an exact time for them to call me meant I could take the call on my lunch break in private.” — Kelly K. (Patient)
“Our schedules are pure chaos. Blocking off specific 30-minute windows for recruitment calls made it manageable. Not having to track people down is a game-changer.” — Sarah L. (Oncology Coord)
Screening Outcomes
66% On-Site Scheduled
18% EMR DNQ
16% No Longer Int.
The Cost of Time: Increase in drop-off directly correlates to time lapse. Patient conviction is fickle; they lose interest as time goes on.
On-Site Conversion
89%

On-Site to ICF Ratio

Final Enrollment
18% Under Average

Study average screen fail rate reduction.

Path 3: Email Intro

< 24h Connection
31%
The Critical Window: This is the probability a candidate will pick up the phone within 24 hours. It is the absolute highest it will be for all delayed outcomes.
“Honestly, by the time they reached out three days later, I figured I wasn’t a fit and had already applied to something else online.” — Susan R. (Patient)
“It broke our hearts to get a list of qualified patients who genuinely wanted to participate, but we just couldn’t get ahold of them. Calling early helps us bring more people in.” — Elena V. (Derm Clinic)
Screening Outcomes
56% On-Site Scheduled
18% EMR DNQ
26% No Longer Int.
Delayed Outreach
22%
(48 Hours)
14%
(72 Hours)

Connection drops rapidly. Unreachable and NLI segments grow as momentum is lost.

4th Outreach
8%

End of standard path. Extremely high abandonment.

Clinical Site Best Practices

Hover over each practice to understand why it maximizes your enrollment conviction.

Allow Live Transfers
Patients in momentum are exponentially more likely to schedule. Removing the callback completely eliminates phone tag and captures the highest possible patient conviction.
Block 30-Min Call Sections
Dedicating two specific 30-minute blocks daily protects your time and guarantees patients are contacted precisely when they expect it, streamlining your entire workflow.
Outreach: 24h & 3x in 72h
Call within the first 24 hours, and attempt 3 times within 72 hours. Connection probability plummets after the first day; structured, rapid persistence saves leads.
Respond to Connecting Email
A prompt reply to our introduction emails signals to the patient (and us) that your site is engaged, highly organized, and ready to take excellent care of them.
Provide Screening Date Availability
Enables true 1-to-1 patient matching. When we know your open slots, we can book patients directly into your calendar, drastically reducing friction for both you and the patient.
Communicate Unreachable Status
If a lead goes cold, tell us immediately. We can re-engage them through our ‘Mother Goose’ protocol rather than burning your limited and valuable site resources.

The Clinical Enrollment Philosophy

What is Clinical Enrollment’s site philosophy?
We understand how busy and often overworked clinical sites are, and how deeply you care about providing the best possible medical care for each patient. At Clinical Enrollment, our philosophy is simple: one perfect patient is better than 100 referrals. We do not aim to overwhelm sites with quantity. We aim to be hyper-specific with quality, matching patients to exact screening dates through a rigorous triple-screening process—online, phone, and medical record retrieval. At the end of the day, we understand these are human beings with health conditions exploring experimental medicine to find hope. We treat them like human beings, not numbers. For our site partners, the best service we can provide is one highly qualified, highly convicted patient every single time.
What is “Patient Conviction” and why does it matter?
Simply being qualified for a study is only half the battle. Qualification is the necessary first step, but patients must also want to participate. Patient conviction can be very fickle. These individuals are making significant medical decisions and need to feel momentum, to feel seen, and to feel heard. This is why immediate outreach—like our warm transfers and scheduled calls—yields drastically better connection and enrollment statistics. When we or our site partners reach out within the first 24 hours, patients feel like they are in the process. They feel taken care of, they know the next steps, and their conviction solidifies.
What makes a great clinical site to partner with?
A great clinical site understands that trial participants are patients making vulnerable medical decisions who need to be nurtured. They are excellent communicators with both the Sponsor and Clinical Enrollment. They transparently inform us how many patients they can realistically screen in a month, they know their screening windows, and they account for trial variability. Most importantly, they spend time and are considerate with each patient. They make the extra phone call to check in. These small, sometimes unscalable activities separate great sites from good ones. The goal for any site is to successfully enroll a handful of patients, not process 50 leads—and those small, non-scalable acts of care are what ensure that actually occurs.
Why do we choose to pull EHRs in 3 days?
Traditionally, taking up to a month to pull and review medical records slows down the entire enrollment process. Tracking down these extended records is incredibly burdensome for sites and destroys patient momentum. Clinical Enrollment takes that responsibility on ourselves to accelerate speed. We ensure that you can communicate with the patient with a full clinical picture within 3 to 5 days. We want sites to be able to call patients right away, fully informed, rather than waiting weeks or a month to gather the necessary medical history.
How does the “Mother Goose” protocol work?
It is our proprietary patient-nurturing step. Between the initial screening and the site introduction, we act as a guide. We educate the patient on the realities of clinical trials, answer their preliminary fears, and set concrete expectations. This hand-holding ensures that when they finally speak with your site, they aren’t just curious—they are prepared, informed, and ready to consent.
What is the recommended cadence if a patient misses the initial call?
While speed-to-lead is critical, we recognize life happens. If a patient misses the initial connection, we recommend a secondary outreach within 24 hours, followed by a final touchpoint at 72 hours, leaving empathetic, clear voicemails each time. If they remain unreachable, sites should transparently communicate this back to Clinical Enrollment so we can re-engage them through our Mother Goose protocol rather than burning site resources.

Ready to Change the Trajectory of Your Enrollment?

Whether you are a clinical site looking to eliminate friction or a sponsor needing predictable, convicted patient funnels—we are ready to partner.

For Clinical Sites

Stop chasing cold leads. Join our network of elite sites receiving fully vetted, highly convicted, warm-transferred patients.

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For Sponsors & CROs

Stop burning budget on top-of-funnel volume. Deploy our white-glove architecture to ensure your sites actually enroll the leads we generate.

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